A lot of critical trials were held concerning Vicodin and its main components. All of these trials proved Vicodin to be an efficient remedy for treatment different diseases and pain relieving. The following trial shows how hydrocodone, the main component of Vicodin, helps to treat ankle sprain.
The authors of this trial are: Hewitt DJ, Todd KH, Xiang J, Jordan DM, Rosenthal NR, CAPSS-216 Study Investigators
The following affiliations took part in the trial: PriCara, Unit of Ortho-McNeil, Inc., Raritan, NJ 08869-0602, USA. dhewitt1@ompus.jnj.com
Publication date & source: 2007-04, Ann Emerg Med., 49(4):468-80, 480.e1-2. Epub 2006 Nov 20.
This publication belongs to different types, such as: Comparative Study, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov’t
The objectives of the study are: This randomized, multicenter study compares the analgesic efficacy and safety of tramadol/acetaminophen versus hydrocodone/acetaminophen versus placebo for the treatment of acute musculoskeletal pain caused by ankle sprain. The methods of the study are: Adults were enrolled with ankle sprain with a diagnosis of partial ligament tear, pain visual analog scale score of 50 to 100 mm (0=”no pain,” 100=”extreme pain”), and pain numeric rating scale score of 2 to 3 (0=”none,” 3=”severe”). Patients reported pain intensity on these scales and pain relief (-1=”pain worse,” 4=”complete relief”) hourly for 4 hours after the first dose of tramadol/acetaminophen 75 mg/650 mg, hydrocodone/acetaminophen 7.5 mg/650 mg, or placebo, and daily for 5 days, with as-needed dosing. We got the following results: Tramadol/acetaminophen (n=192) and hydrocodone/acetaminophen (n=204) provided greater total pain relief than placebo (n=207; P<.001) during the first 4 hours (mean scores [95% confidence interval (CI)] 6.6 [95% CI 6.1 to 7.1], 6.8 [95% CI 6.3 to 7.3], and 5.4 [95% CI 4.9 to 5.9], respectively; possible range -4 to 16), decreased pain intensity during the first 4 hours, and increased average pain relief on days 1 to 5. No efficacy measure was significantly different between the tramadol/acetaminophen and hydrocodone/acetaminophen groups. Common adverse events included somnolence, nausea, dizziness, and vomiting. Conclusion: One or 2 capsules of 37.5 mg tramadol/325 mg acetaminophen and 1 capsule of 7.5 mg hydrocodone/650 mg acetaminophen were well tolerated, had comparable clinical utility, and were more effective than placebo in the management of acute musculoskeletal pain caused by ankle sprain.